Terraria: How to Get Tissue Sample (Easy) | Full Guide 2023

Evil biomes in Terraria have their fair share of resources you must use to progress through Hardmode. Although uncontrollable and hard to traverse, the reward is worth the risk you’re going through, especially in Crimson.

Prepare your weapons (or if you don’t have any, do more traveling) and arena as we guide you on how to get Tissue Samples. We’ll also give extra strategies and tips to maximize the item once it’s in your Inventory.

What is a Tissue Sample?

A Tissue Sample is a Crimson-exclusive crafting material in Terraria. You can make 12 uniquely themed items, alongside Crimtane Bars, that are usually upgrades to basic tools in Pre-Hardmode.

Almost every monster in the Crimson biome drops Vertebra – another important component for making several boss-summoning materials. However, only the Brain of Cthulhu and its Creepers drop Tissue Samples.

The table below shows all entities dropping the item in all modes, with their corresponding quantities and chances:

Note that Creepers dropping the item decrease in chance the harder mode in Terraria the player’s in. We recommend preparing an arena by placing cheap Platforms inside the Underground Crimson. Consider the following items as well:

• Campfires
• Banners from biome entities
• Torches
• Ropes

It’s unnecessary to defeat the Brain of Cthulhu during combat, as its minions always drop Tissue Samples. However, you can expect more rewards for defeating the boss.

Alternatively, you can insert a Shadow Scale to get a Tissue Sample from the Chlorophyte Extractinator.

Crafting

Here are all items you can make with the Tissue Sample: